Only one ship stands between earth and total annihilation! The High Mobile Battleship Nadesico is the most formidable fighting machine ever conceived, but due to a shortage of trained soldiers, the crew is a little unorthodox. The poor Jovians don't stand a chance against the largest contingent of geeks and misfits ever sent into orbit!

Tekkaman Blade takes place in the year 2300 AD. On a certain moment, the Radam attack Earth. A few months after the beginning of the invasion, a Tekkaman appears, he calls himself Blade and with the help of the Space Knights, Blade starts to fight the Radam. But there are a few things that Blade isn't telling about his past.

Set in modern Italy, story follows a group of traumatically-injured young girls taken from hospitals all over the country, who are then cybernetically enhanced, indoctrinated and trained to be assassins by a secret branch of the Public Corporation for Social Welfare, Section 2. Each girl is assigned to a male "handler" who oversees her training, deployments, and general conduct. Each handler is free to "condition" his cybernetic assassin to the extent he sees fit, which increases a girl’s lethality and loyalty at the expense of human individuality and lifespan.