Agent Phil Coulson of S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement and Logistics Division) puts together a team of agents to investigate the new, the strange and the unknown around the globe, protecting the ordinary from the extraordinary.

Aspiring super-villain Dr. Horrible wants to join the Evil League of Evil and win the girl of his dreams, but his nemesis, Captain Hammer, stops him at every turn.