Aspiring super-villain Dr. Horrible wants to join the Evil League of Evil and win the girl of his dreams, but his nemesis, Captain Hammer, stops him at every turn.

Agent Phil Coulson of S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement and Logistics Division) puts together a team of agents to investigate the new, the strange and the unknown around the globe, protecting the ordinary from the extraordinary.