Physician Carole Nelson, suspected of having ties to notorious gangster Joe Gurney, must prove her innocence or the Medical Board will revoke her license. When Gurney seeks her out for treatment after being shot, it could be the break Nelson needs. Now she has a chance to use her medical know-how to outwit Gurney and his goons and reestablish her professional reputation.

While on their honeymoon, a reporter and his new bride stumble upon a ring of fifth columnists.

Choreographer Bob Connolly and prolific screenwriter Crane Wilbur teamed up on the direction of Warner Bros.' The Patient in Room 18. Patric Knowles delivers a delightfully comic performance as Lance, an outwardly normal young man obsessed with detective stories. When his obsession threatens to lapse over into lunacy, Lance is sent to the hospital for a nice long rest. It isn't long before he gets mixed up in a genuine murder mystery, using his second-hand knowhow to solve the case. Up-and-coming Ann Sheridan is quite amusing as Lance's nurse and confidante, while the murderer is played by a fellow who is usually cast as the murder victim.