Entropy is a semi-autobiographical film which tells the story of a young director struggling to make a film for a despotic studio while his life falls apart around him. Along the way, he goes on tour with U2 to help them make a music video, gets married in Vegas, and has a conversation with his cat.

A psychiatrist becomes romantically involved with the sister of one of his patients, but the influence of her controlling gangster husband threatens to destroy them both.

A hardened New Orleans cop, Dave Robicheaux, finally tosses in the badge and settles into life on the bayou with his wife. But a bizarre plane crash draws him back into the fray when his family is viciously threatened.