Lisa Templeton begins a new job as a cleaner at High Hopes Hospital, a mental institution in Amityville, Long Island. Initially delighted to get the job, Lisa soon realises that all is not as it seems. Intimidated by staff and the psychotic ramblings of the patients, she is further unnerved by apparent supernatural occurrences on the night shift. To preserve her sanity Lisa must uncover the mysterious history of the institution and it's inmates. But the truth is far more terrifying than she could ever imagine.

A 19th century woman, who has become one of the undead, acts as a hired killer in modern times. When she starts knocking off part of the elite businessmen, "The Illuminati", who secretly are taking over business and the government, she becomes the target of a hired Scotland Yard detective. Of course, the head of "The Illuminati" is the vampire who first gave her immortality