Small town artist Charley is a tortured man whose drinking binges blur with his sneaking suspicion that he might be a werewolf. He distances himself from those he loves and sinks deeper into solitude, as his flashes of memory of his grisly nighttime acts manifest themselves through his artwork.

It's autumn in New York. Sam has broken up with his girlfriend and his father has recently died. World-weary and sloppy drunk, he finds temporary solace in the arms of Anna, a mysterious vampire who draws him away from his friends and into a web of addiction and madness.

A family from the city decide to spend a weekend away at a friend's country farmhouse. But a fluke accident sets off a chain of events that alters their lives forever and conjures up the ferocious spirit of the Wendigo.