Sportswriter Andy Farmer moves with his schoolteacher wife Elizabeth to the country in order to write a novel in relative seclusion. Of course, seclusion is the last thing the Farmers find in the small, eccentric town, where disaster awaits them at every turn.

Test pilot Tuck Pendleton volunteers to test a special vessel for a miniaturization experiment. Accidentally injected into a neurotic hypochondriac, Jack Putter, Tuck must convince Jack to find his ex-girlfriend, Lydia Maxwell, to help him extract Tuck and his ship and re-enlarge them before his oxygen runs out.