An anthology of eleven vignettes featuring star-studded casts of extremely unique individuals who all share the common activities of conversing while drinking coffee and smoking cigarettes.

A brother and sister, sitting in a coffee bar, bicker mildly about whose idea it was to come to Memphis and which kind of cigarette is fresher. Danny, their waiter, comes by offering refills; after determining they are twins, he guesses which is the evil one. Without a pause, he sits down and offers his theory about Elvis's twin. He drones on. The good twin finally speaks up, giving her own opinion. The waiter is unfazed. After his boss finally calls him back to work, the twins are free to resume their bickering amidst the coffee and cigarettes.

Salvatore "Sal" Fragione is the Italian owner of a pizzeria in Brooklyn. A neighborhood local, Buggin' Out, becomes upset when he sees that the pizzeria's Wall of Fame exhibits only Italian actors. Buggin' Out believes a pizzeria in a black neighborhood should showcase black actors, but Sal disagrees. The wall becomes a symbol of racism and hate to Buggin' Out and to other people in the neighborhood, and tensions rise.

The story of Nola Darling's simultaneous sexual relationships with three different men is told by her and by her partners and other friends. All three men wanted her to commit solely to them; Nola resists being "owned" by a single partner.

Dr. Hess Green becomes cursed by a mysterious ancient African artifact and is overwhelmed with a newfound thirst for blood. Soon after his transformation he enters into a dangerous romance with Ganja Hightower that questions the very nature of love, addiction, sex, and status.

During the summer of 1977, a killer known as the Son of Sam keeps all of New York City on edge with a series of brutal murders.

Infatuated with the idea of becoming rich, college student Jonathan Corliss secretly dates Dorothy Carlsson to gain the approval of her wealthy father. When Dorothy tells Jonathan that she is pregnant and that her father will deny her inheritance if he finds out, Jonathan murders her, but he stages her death as a suicide. As Jonathan works his way onto Mr. Carlsson's payroll, Dorothy's twin sister, Ellen, investigates the apparent suicide.

Talented but self-centered trumpeter Bleek Gilliam is obsessed with his music and indecisiveness about his girlfriends Indigo and Clarke. But when he is forced to come to the aid of his manager and childhood friend, Bleek finds his world more fragile than he ever imagined.

Reunited after a 17-year separation, Walter, an Angolan immigrant, is joined in the U.S. by his wife and teenage daughter. Now absolute strangers sharing a one-bedroom apartment, they discover a shared love of dance that may help overcome the emotional distance between them.