Jack Carter, a mob enforcer living in Las Vegas, travels back to his hometown of Seattle for his brother's funeral. During this visit, Carter realizes that the death of his brother was not accidental, but a murder. With this knowledge, Carter sets out to kill all those responsible.

Jeremiah Ecks, an FBI agent, realizes that he must join with his lifelong enemy, Agent Sever, a rogue DIA agent with whom he is in mortal combat, in order to defeat a common enemy. That enemy has developed a "micro-device" that can be injected into victims in order to kill them at will.