New York City, 1957. Lionel Essrog, a private detective living with Tourette syndrome, tries to solve the murder of his mentor and best friend, armed only with vague clues and the strength of his obsessive mind.

Best friends since they were kids, Rabbi Jacob Schram and Father Brian Finn are dynamic and popular young men living and working on New York's Upper West Side. When Anna Reilly, once their childhood friend and now grown into a beautiful corporate executive, suddenly returns to the city, she reenters Jake and Brian's lives and hearts with a vengeance. Sparks fly and an unusual and complicated love triangle ensues.