Blossom Russo is a highly intelligent and spunky teenager. The youngest of three, she lives with her divorced musician father, Nick, eldest brother and recovering substance abuser Anthony, and decidedly not-so-bright middle brother Joey. Along for the ride is Blossom's ditzy best friend, Six, who sometimes shows flashes of great perception.

After being a passenger in a hit-and-run, Donna Patterson is sent to reform school, taking the rap for the driver, bad boy Vince. Inside, she makes friends and self-discoveries while trying to save her little sister from their abusive uncle.

A bright young medical student must solve the frightening mystery that plagues the children of a small Midwestern town.