The Cortez brothers rob a bank and flee beyond the Mexican border. On their trail are various people, each for a different reason: Sheriff Fulton is sent by the robbed bank to recuperate the money; Django, a head-hunter, is after them for the reward money; Pickwick is after a saddle stolen from him by the Cortez brothers; Pedro and Dolores, saloon owners, also would like to have the loot.

In a remote village in occupied Europe, the SS pursue their inhuman treatment of captured partisans in efforts to force them to betray their comrades.... while Fraulein Krast, a sadistic biologist, concentrates her efforts on the womenfolk with refined tortures and humiliation, leaving them to the mercy of a sex-crazed half-man, half-beast she has created with experimental injections.... And as advancing Allied forces approach the village, Krast herself becomes a victim of her own fiendish rituals....