Season one is set in the year 2258 aboard a five-mile-long, totally self-sufficient United Nations-like space station. Babylon 5 is where humans and aliens try to work out their differences peacefully, in neutral territory full of mystery, suspense, and adventure. The space outpost is a hotbed of interplanetary intrigue, conspiracies, and betrayals among myriad life-forms living and working together.

The Starfleet vessel USS Enterprise sets out on a five-year mission to explore new worlds and seek out new lifeforms in the Alpha Quadrant of the Galaxy. Under the command of Human Captain James T. Kirk and the Vulcan Spock, the Enterprise comes across many strange lifeforms in the first year of its mission – including shapeshifters, androids, and even more bizarre creatures. Elsewhere, there are run-ins with several prominent species, including the warrior race of the Klingons, the Romulan Star Empire, and the Gorn.