A woman has a brief affair with the contractor who is renovating her apartment and he refuses to accept the end of the relationship.

After the 1860s Wild West, a group of misfit settlers - including ex-doctor Phil Taylor, prostitute Belle, and homosexual bookseller Julian - decide they cannot live in their current situation in the west. They hire a grizzled alcoholic wagon master by the name of James Harlow to take them on a journey back to their hometowns in the East.

Unlikely heroes must overcome incredible dangers to save mankind from the threat of an alien invasion.

A seemingly perfect marriage disintegrates, as both husband and wife become involved in a series of affairs.