In a school in northeastern Japan, five friends in the animation club, Aoi, Ema, Shizuka, Misa, and Midori swear to complete a new anime called "Shinbutsu Konkou SHICHIFUKUJIN" with some donuts. Since then, day after day, the five spend all of their time on anime production. The awe of going from rough sketches to animation, and the awkward acting in the after-recording session... The final product was finished at the cultural fair six months later. After they graduated they still pursued animation and swore on some donuts that they would make another anime together.

Go! Princess PreCure is set in a boarding junior high school, named Noble Academy. The protagonist Haruka Haruno is a 13-year-old first-year student. Her big dream is to be a princess someday because she admired a princess in the picture book she has kept since her childhood. One day, she transforms into Cure Flora with the "Dress Up Key" which Prince Kanata of Hope Kingdom gave her as a good luck charm when she was little. Then she also finds other Pretty Cure girls in her school, 14-year-old Minami Kaidou as Cure Mermaid and 13-year-old Kirara Amanogawa as Cure Twinkle. As the Princess Pretty Cure team, with two fairies Pafu and Aroma, they fight against the dark witch Dyspear, who hates all the dreams in the world and wants to turn them to despair.

A mysterious girl named Sakura escaped after her fox friend, Shizuku was arrested. When he managed to escape, she fell to the Human World only to be found by Ichika Usami. Sakura says she is from "Sakuragahara", a world based on ancient Japan that is in danger because a mysterious evil figure named Karasu Tengu has taken over and stolen all the beautiful things in her world. She is also looking for Pretty Cure that represents Sweet, Jewels and Keys. Ichika says that she found the KiraKira PreCure team, which represents sweets. As two Karasu Tengu servants arrived in the human world looking for Sakura, the other members of the KiraKira team were ambushed, only to be saved by Maho Girls PreCure! Team, which represented Jewel and Go! Princess PreCure Team, which represents Key. When they gathered together with Sakura, the three teams had to dare Sakuragahara to save Shizuku and free her world from the evil hands of Karasu Tengu.

In the continent of Astraea, a man falls from the sky, possessing no memories other than his name, Yuuki. An elf named Kokkoro finds him, introducing herself as his guide in the world they are about to traverse. With Kokkoro's guidance, Yuuki is able to learn how this world works, from battling monsters to handling currency.

To earn money for their journey, Yuuki and Kokkoro decide to go to a nearby guild association to accept a simple quest. In their expedition, they meet Pecorine, a somewhat gluttonous but charming girl skilled in battle. The next day, they also meet Karyl, a cat girl specializing in magic.

After some time, a bond of friendship and camaraderie forms between them, and the four decide to create a guild of their own. As they continue their adventures, they explore the world, meet new people, and will perhaps uncover the mysteries behind Yuuki's missing memories.

This is Meiro-machi (Labyrinth Town), the town of fortune-telling. In town, there is a fortune-telling shop called Urara, where girls aspiring to be fortune-tellers come from all over the country. Chiya, who was raised in the mountains, comes to the town with a purpose, but what is it exactly? There, she meets Kon who is always serious, Koume who loves all things western, and the shy Nono. Their fun days of living together as apprentice fortune-tellers are about to begin.