The world is falling into chaos. As he roams a crumbling city, Duncan MacLeod, the Highlander, remembers happier times before the love of his life left... Hopeless and alone, MacLeod finds his way to a band of immortal companions, including his mysterious friend Methos, and a mortal, Watcher Joe Dawson. Together this small group sets out on a quest to find the origin of the first Immortal.

While restoring a fifteenth-century painting Julia reveals a hidden Latin phrase. A series of murders begin to rock her small world of art experts, patrons and restorers, and she finds that the mystery of the painting is interwoven with the mystery of the deaths around her.

Duncan MacLeod cannot die -- he is a 400-year-old immortal, who has seen his share of humanity's history. Still, he risks his life in battle against other immortals and tries to save people from harm.

Immortals Connor and Duncan Macleod join forces against a man from Connor's distant past in the highlands of Scotland, Kell, an immensely powerful immortal who leads an army of equally powerful and deadly immortal swordsmen and assassins. No immortal alive has been able to defeat Kell yet, and neither Connor nor Duncan are skilled enough themselves to take him on and live. The two of them eventually come to one inevitable conclusion; one of them must die so that the combined power of both the Highlanders can bring down Kell for good. There can be only one... the question is, who will it be?

Liquidated after discovering a corporate conspiracy, mild-mannered graphic artist Patience Phillips washes up on an island, where she's resurrected and endowed with the prowess of a cat — and she's eager to use her new skills... as a vigilante. Before you can say "cat and mouse", handsome gumshoe Tom Lone is on her tail, fascinated by both of her personas.

Professor Charles Xavier and his team of genetically gifted superheroes face a rising tide of anti-mutant sentiment led by Col. William Stryker. Storm, Wolverine and Jean Grey must join their usual nemeses—Magneto and Mystique—to unhinge Stryker's scheme to exterminate all mutants.