Werner Herzog follows mountaineers Hans Kammerlander and Reinhold Messner during their expedition into climbing the Gasherbrum mountains, which has some of the most difficult peaks to be conquered, and they'll do it without the use of oxygen tanks. Herzog also takes some time to hear about their past experiences with other mountains, their personal tragedies and the reasons why they are so involved with such activity.

With extraordinary access, BLAST exposes a world of risky, hardcore, scientific adventure. The story follows an international team of astrophysicists trying to launch a multi-million dollar telescope on a NASA high-altitude balloon. Their journey to discover thousands of early galaxies takes them from the Arctic to the Antarctic. Revealing frustrations, inevitable failures and ultimate triumph, BLAST puts a human face on the quest to answer our most basic question - How did we get here?