A girl, abandoned by her mother when she was three, moves to a small town in Florida with her father. There, she adopts an orphaned dog she names Winn-Dixie. The bond between the girl and her special companion brings together the people in a small Florida town and heals her own troubled relationship with her father.

A new case for the cult detectives! Not by coincidence, a mysterious videotape falls into the hands of Jupiter Jones, Pete Crenshaw and Bob Andrews during Jupiter's birthday party in Rocky Beach. On it is a recording of Jupiter's long dead parents. In their message they want to communicate to their son the key to an especially tricky riddle.

The comedic adventures of an introverted boy left on the doorstep of a pair of reluctant, eccentric great-uncles, whose exotic remembrances stir the boy's spirit and re-ignite the men's lives.