When a Black doctor develops a serum that is supposed to regenerate dying liver cells and tests it on himself, it accidentally turns him into an albino monster with a lust for murdering prostitutes, pimps and drug dealers.

"Boxcar" Bertha Thompson, a transient woman in Arkansas during the violence-filled Depression of the early '30s, meets up with rabble-rousing union man "Big" Bill Shelly and the two team up to fight the corrupt railroad establishment.

Jack Spade returns from the army in his old ghetto neighbourhood when his brother, June Bug, dies. Jack declares war on Mr. Big, powerful local crimelord. His army is led by John Slade, his childhood idol who used to fight bad guys in the 70s.