It was a normal night in Las Vegas, Nevada, all the lights were flashing brightly, until a man with one hand, one eye, and one leg walks into a pawn shop with a statue of a hideous looking Leprechaun. The owner claims it's a good luck charm. The statue also wore a medallion around it's neck. The careless pawn shop owner took off the medallion setting the Leprechaun free...

When a fearless enemy out for revenge unleashes a brutal and deadly new virus, BSAA captain Chris Redfield enlists the help of Agent Leon S. Kennedy and Professor Rebecca Chambers to bring down the death merchant and save New York City.