Humans have created a Wall of Severance to separate themselves from the bears, who grew violent and attacked humans after a far-off planet known as Kumalia exploded many years ago, turning into a meteor shower that fell upon earth. Two bears, Ginko Yurishiro and Lulu Yurigasaki, sneak through the Wall of Severance and disguise themselves as humans, enrolling in Arashigaoka Academy and taking an interest in Kureha Tsubaki, a human girl who despises bears.

宇宙中的一场爆炸让地球上的熊类发生了暴走，身强体壮的熊类很快就让人类伤亡惨重，一场旷日持久的人熊之战就此拉开序幕。为了生存，人类建起了高耸的墙壁，将熊隔离在了墙壁之外。然而，他们并不知道的是，在这个世界上，危险的并不仅仅是那些凶猛强壮的野兽们。
岚丘学园学院中，来了两名转校生，她们是百合城银子（荒川美穂 配音）和百合咲露露（生田善子 配音），表面上看来，她们只是柔软可爱的女孩子，然而，两人的真实身份，竟然是可以化身成为人类的熊。外冷内热的椿辉红羽（山根希美 配音）、外柔内刚的泉乃纯花（小仓唯 配音）、善良开朗的百合园蜜子（悠木碧 配音），在百合城银子和百合咲露露的眼中，她们都是散发着香味的猎物。

In the town of Most City, a publishing house resides in the second story of an old building. The staff prints a monthly science magazine about the most shocking phenomena that even scientists find impossible. The handsome editor-in-chief, Taro, is assisted by grade-schooler Jiro and his dog, Saburo. But when scientist Goro Sato seeks their help, it sparks the beginning of a bizarre new tale...