Ten years after the Fourth Holy Grail War, a devastating clash between Masters and Servants, another war erupts. Shirou Emiya, whose father fought in the first battle, was leading a peaceful life with the warmhearted Sakura Matou. But when hidden forces begin to stir, Shirou resolves to fulfill his father’s dying wish, protect Sakura, and fight for the Holy Grail.

Natsume Takashi has the ability to see spirits, which he has long kept secret. However, once he inherits a strange book that belonged to his deceased grandmother, Reiko, he discovers the reason why spirits surround him.

The battle rages on as Shirou continues to protect Sakura, now consumed by the darkness. He joins forces with Rin to end the Holy Grail War, while Illyasviel, who knows the truth behind it, confronts her fate. Amidst the chaos, Zouken plots to manipulate Sakura for his own desires. The final fight begins.

For as long as he can remember, Ichigo Kurosaki has been able to see ghosts. But when he meets Rukia, a Soul Reaper who battles evil spirits known as Hollows, he finds his life is changed forever. Now, with a newfound wealth of spiritual energy, Ichigo discovers his true calling: to protect the living and the dead from evil.

Kaede Honjou is invited by her friend Risa Shiramine to play a virtual reality MMO game with her. While Kaede doesn't dislike games, what she really, truly dislikes is being in pain. She creates a character named Maple, and decides to put all her points in VIT to minimize pain. As a result, she moves slowly, can't use magic, and even a rabbit can get the best of her. But as it turns out, she acquires a skill known as "Absolute Defense" as a result of her pumping points into VIT, as well as a "Counter Skill" that works against special moves. Now, with her ability to nullify all damage, she goes on adventures.