The film tells the story of two good friends who live together, Andrew, an agoraphobic travel agent who works from his home, and Dave, a loser who works in an office where he is treated with contempt. Just when it seems things can't get any worse for the two, the entire world outside of their house disappears and is replaced with an endless white void.

A look at the 1950s muscle men's magazines and the representative industry which were popular supposedly as health and fitness magazines, but were in reality primarily being purchased by the still-underground homosexual community. Chief among the purveyors of this literature was Bob Mizer, who maintained a magazine and developed sexually inexplicit men's films for over 40 years. Aided by his mother, the two maintained a stable of not so innocent studs.

In late 1970s Ohio, a group of friends filming a homemade zombie movie witness a devastating train derailment. Soon after, their quiet town is gripped by unexplained disappearances, strange phenomena, and a growing sense of fear, as they uncover that something terrifying has been set loose.

A group of strangers find themselves trapped in a maze-like prison. It soon becomes clear that each of them possesses the peculiar skills necessary to escape, if they don't wind up dead first.