In 1828 the town of Flat Ridge is over run by a band of outlaws looking for lost treasure said to be buried somewhere in town. In their quest for dominance, the outlaws kill Sally, a prostitute who happens to be the sister of Rachel and a former member of the disbanded Rose Gang. With the weight of grief on her heart, Rachel decides to shed her new found religious faith to bring vengeance upon her sister's killers. After laying Sally to rest, Rachel goes in search of her former posse to assist her in avenging her sister's death.

Mikey and Rose are professional assassins. They are also lovers, and once upon a time Rose also knew Mikey's father. During an elaborate hit job for a malicious gangster, Rose fails to kill the main target, the gangster's pregnant girlfriend. Instead, she delivers her baby and convinces Mikey to help her protect them both. As Rose weakens from cancer, Mikey becomes breadwinner for this unusual family. But tranquility will not last.

A reticent piano player Percival, along with Rooster, his flamboyant lead performer and manager, struggle to keep their speakeasy, in the Prohibition-era South, out of the hands of gangsters who want to take it over.

After returning from her first space mission, astronaut Sam Walker is placed under NASA’s care at a high security house for rehabilitation and medical testing. However, when disturbing occurrences begin happening around the property, she fears that something extraterrestrial has followed her back to Earth