In Argentina, between 1982 and 1985, the Puccios, a well-established family of San Isidro, an upper-class suburb of Buenos Aires, kidnap several people and hold them as hostages for a ransom.

ZeroZeroZero series follows the journey of a cocaine shipment, from the moment a powerful cartel of Italian criminals decides to buy it until the cargo is delivered and paid for, passing through its packaging in Mexico and shipment across the Atlantic Ocean.