One morning, Louise, 45, is suddenly unable to step out of her car. Sweats, anxieties, palpitations... she is having an inexplicable panic attack. She is tetanized and simply cannot set foot outside.

Stéphanie, a police officer working for Internal Affairs, is assigned to a case involving a young man severely wounded during a tense and chaotic demonstration in Paris. While she finds no evidence of illegitimate police violence, the case takes a personal turn when she discovers the victim is from her hometown.

The story revolves around Estelle, an incomparably professional long-haul pilot/captain who leads a perfectly structured life alongside her loving and protective husband Guillaume. Everything seems to be going well, although the endless flights and bouts of "jet lag" are beginning to upset the young woman’s biorhythms, especially her sleep. One day, in a corridor in Nice airport, she randomly crosses paths with Ana, a photographer she’d had a passionate affair with twenty years earlier. Estelle has no way of knowing that this reunion will suck her into a nightmaresque spiral and lure her life into irrationality...

After landing her dream job in Paris, Chicago marketing exec Emily Cooper embraces her adventurous new life while juggling work, friends and romance.