故事发生在西汉初年，成就一世功业的汉高祖刘邦驾崩，虽然生前平定了韩信、彭越、英布等开国功臣的叛乱，却无法阻止皇后吕雉（刘雪华 饰）的专权。在这个强势女人的阴影下，刘氏宗族惨遭屠戮，锦衣卫首领刘宣（赵文卓 饰）被迫充当吕氏鹰犬，对同族亲眷痛下杀手。他和兄长刘湘（孙岩 饰）共同喜欢吕后的侄女琴子（高圆圆 饰），这段复杂的感情无疑成为兄弟俩矛盾的根源。偶然机缘，刘宣结识了名医淳于意那个调皮顽劣却纯真可爱的女儿缇萦（贾静雯 饰），故事又朝着未知的方向发展。
乱世初定，汹涌的权力斗争中，爱恋的男女随波逐流……

In 1937, during the height of the Second Sino-Japanese War, the Imperial Japanese Army has just captured Nanjing, then-capital of the Republic of China. What followed was known as the Nanking Massacre, or the Rape of Nanking, a six week period wherein tens of thousands of Chinese soldiers and civilians were killed.

The story of a father's tireless love for his autistic son. A terminally ill father's attempt to teach his autistic son the necessary life skills to survive on his own before he passes away. It is also a poignant tribute to the infinite love that parents have for their children and their unending desire to take care and look after them to their best abilities, no matter the struggle, no matter the effort.

For never-do-well compulsive gambler Fong, there's only one thing more fearsome than debtors at his doorstep - having to coax a crying baby. But what if the baby becomes his golden goose to fend off his debtors? Can he overcome his phobia of diapers, milk bottles, and cloying lullabies?