In an era where aliens have invaded and taken over feudal Tokyo, an unemployed samurai finds work however he can.

The future’s looking bleak. It’s a good thing there’s a new sheriff in town. Her name is Jo and she’s an enigma even to herself. Alongside her partners Sei, Amy, and Meg, Jo fights for the citizens who can’t defend themselves. Confronting corruption and twisted science, these gals are on fire—and they’re the best chance the wounded city’s got.

In this world, Sensha-do (戦車道), the art of tank-combat, is a traditional Japanese martial art for girls. Miho, a girl who just transferred into the Ōrai Girls' Academy in Ibaraki Prefecture, has been ordered by the academy's student council chairperson to join the school team and compete in the national Sensha-do championships.