Raj is a rich, carefree, happy-go-lucky second generation NRI. Simran is the daughter of Chaudhary Baldev Singh, who in spite of being an NRI is very strict about adherence to Indian values. Simran has left for India to be married to her childhood fiancé. Raj leaves for India with a mission at his hands, to claim his lady love under the noses of her whole family. Thus begins a saga.

Rizwan Khan is an autistic Muslim from the Borivali section of Mumbai. He marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who treat him as a terrorist because of his disability and his race.

Per her mother's last wish, an 8 year old girl sets out to reunite her father with his college best friend who was in love with him.