On the way to meet with an independent artist in the South, newlywed art dealer Madeleine is convinced by her husband, George, that they should stop to meet his family in North Carolina. Madeleine's affluent lifestyle clashes with the family, but she befriends George's wide-eyed and pregnant sister-in-law, Ashley, who is nearing her due date. Through the family, Madeleine gains greater insight into George's character.

Famed forensic psychiatrist Dr. Jack Gramm enjoys a reputation as one of the most sought-after profilers around. His expert testimony has resulted in the conviction of many criminals, including serial killer Jon Forster. On the eve of Forster's execution, one of Gramm's students is murdered in a vicious copycat crime, and Gramm himself receives an ominous message informing him that he has less than 90 minutes to live.

A wealthy playboy named Bruce Wayne and a Chicago cop named Jim Gordon both return to Gotham City where their lives unexpectedly intersect.