A group of scientists, led by a Professor Ortmann, produce a living human child using scientific processes — a "homunculus." This creature is human in every way, except that he cannot experience love.

In this apparently lost film, a beautiful dancer's sexual allure is used by an evil cripple to entice men to their deaths. Falling in love with one of the potential victims, she is told by the cripple that he will set her free if her lover, actually a murderer himself, survives and escapes a bizarre labyrinthe which runs beneath the cripple's house.

A group of scientists, led by a Professor Ortmann, produce a living human child using scientific processes - a "homunculus." This creature is human in every way, except that he cannot experience love.

The homunculus and his companion Edgar Rodin make an invention that would allow the hateful homunculus to destroy the world. But first he wants to find out about love. When he observes how young Anna is rejected by her parents, he takes care of her and asks her parents for forgiveness - without success. He brings her to her seducer, who also rejects the girl. The homunculus then takes revenge by ruining the man financially and throwing Anna at his feet. But she still loves the villain and asks Homunculus for mercy. The homunculus cannot understand this feeling of love - he wants to try it out on himself. He puts a young woman who loves him to the hardest test, but she will do anything for him, sacrificing her fiancé and her parents. Only when he reveals his artificial nature to her, she leaves him. This experience confirms the homunculus in his intention to destroy mankind.

Richard Ortmann the artificial man (Homunculus) has become the head of the corporation that represents the capital and power of the country, but he has stopped believing in human love. All the more clear is his goal now: the annihilation of mankind.

Part of the artificial-creature series encompassing Der Golem (1914 and 1920), Alraune (1918, 1928, 1930) and Metropolis (1926), 'Homunculus' was the most popular serial in Germany during World War I even influencing the dress of fashionable Berlin. Foenss, a Danish star, is the perfect creature manufactured in a laboratory by Kuehne. Having discovered his origins, that he has no 'soul' and is incapable of love, he revenges himself on mankind, instigating revolutions and becoming a monstrous but beautiful tyrant, relentlessly pursued by his creator-father who seeks to rectify his mistake.

Suddenly appearing in Florence, an evil seductress causes Cesare, the city's ruler, and his son to both fall madly in love with her. The son, killing his father before an order to torture the woman can be carried out, then turns the city's churches into dens of sexual debauchery. Acts of evil and corruption continue unabated until the arrival of Death, who brings with her a horrible plague which she is about to loose upon the city.