Chronicle of a Disappearance unfolds in a series of seemingly unconnected cinematic tableaux, each of them focused on incidents or characters which seldom reappear later in the film. Among the many unrelated scenes, there is a Palestinian actress struggling to find an apartment in West Jerusalem, the owner of the Holy Land souvenir shop preparing merchandise for incoming Japanese tourists, a group of old women gossiping about their relatives, and an Israeli police van which screeches to a halt so several heavily armed soldiers can get off the car and urinate.

An examination of the creation of the state of Israel in 1948 through to the present day. A semi-biographic film, in four chapters, about a family spanning from 1948 until recent times. Combined with intimate memories of each member, the film attempts to portray the daily life of those Palestinians who remained in their land and were labelled "Israeli-Arabs," living as a minority in their own homeland.