Yayoi Sakamoto, a diehard fan of comedians and comedy acts, enrolls in the private Kazuki High School in Nanba (Osaka's entertainment district famous as the starting point for many comedians). She reunites with Yomogi Takahashi, a childhood friend who once formed the comedy duo "Konamonzu" with her when they were little. Before long, they find themselves putting together a routine at a park like they did before, in order to enter a local shopping area's contest. At that moment, a mysterious girl calls out to them.

Japari Park is an enormous integrated zoo built somewhere in this world. A mysterious substance found there, called "Sand Star," causes the animals to turn into humanoid beings called "Animal Girls"! These new creatures spend every day peacefully with the zoo's visitors... but after some time, a lost child turns up in the park. The child's attempt to find the way home turns into a great adventure with the Animal Girls!

Long ago, the most ancient of divine dragons was slain by a human. The mighty dragon accepted its death when suddenly, it was reborn as Dolan, a man who lives in a quiet village. While spending another peaceful day toiling in the fields, he meets Celina, a half-human, half-snake creature looking for a partner. The unlikely duo become friends, but challenges lie ahead that threaten their new bond.

A girl named Mitsuki Kanzaki lives with her step-brother Yuya after her mother remarries. One day, Mitsuki is possessed by the self-proclaimed spirit of a young girl, Hiyori Kotobuki. Hiyori (in Mitsuki's body) must fall in love with Yuya to move towards the "Gates of Heaven."

Set in a futuristic world, there exist "Toys" which grant people superhuman abilities. This is responsible for a wave of crimes and necessitates employing Toy-using detectives to help solve them. Opera Kobayashi runs a detective agency, Milky Holmes, staffed by four aspiring young girl detectives who attend the Holmes Detective Academy, and each girl possesses their own unique Toy.