When Van Helsing's mysterious invention, the "Monsterfication Ray," goes haywire, Drac and his monster pals are all transformed into humans, and Johnny becomes a monster. In their new mismatched bodies, Drac and Johnny must team up and race across the globe to find a cure before it's too late, and before they drive each other crazy.

Dracula, Mavis, Johnny and the rest of the Drac Pack take a vacation on a luxury Monster Cruise Ship, where Dracula falls in love with the ship’s captain, Ericka, who’s secretly a descendant of Abraham Van Helsing, the notorious monster slayer.