Megumi Noda, or "Nodame" is a piano student at Momogaoka College of Music. An extremely talented pianist who wants to be a preschool teacher, she prefers playing by ear rather than reading the music score. She is messy and disorganized. Shinichi Chiaki is Momogaoka's top student. Born into a musical family, he is talented in piano and violin and has secret ambitions to become a conductor. An arrogant multi-lingual perfectionist who once lived abroad in the music capitals of the world as a young boy, he is trapped in Japan because of his childhood phobia of airplanes and the ocean. They meet by accident and sparks fly!

Rio Sanada is the president of "Sanada Wellness" and an up-and-coming businesswoman who is selected as one of the "100 people in their 30s who will change the world". She is reunited with her former love interest Daiki Miyazaki, who is now a detective, after 15 years as an important witness to a murder case.

In Gifu Prefecture in 2006, Rio is a third-year high-school student who wants to go to the University of Tokyo. She took good care of her younger brother in lieu of their busy father. Before Daiki could confess to her, an incident occurs at the dormitory.

《龙樱2》漫画于2018年1月26日在讲谈社旗下《周刊Morning（Weekly Morning）》上开始连载。这回讲述的是面对2020年日本教育制度改革，律师樱木建二再次回到龙山高中，又一次缔造升学名校奇迹的故事。