在这个世界上，存在着一种名为“怪灵”的生物。故事发生在弗塞亚学院之中，在那里，设立了名为“脑机能异常对策室”的机构，专门解决怪灵带来的危险和麻烦。一条晴彦（下野紘 配音）是一年级新生，亦是对策室的成员，他拥有能够使用绘画封印怪灵的能力，是足智多谋的军师。
川神舞（上坂堇 配音）是一条晴彦的学姐，个性开朗行事冲动的她常常惹出不少的麻烦，和晴彦组成了搭档相互取长补短居然格外的般配。除此之外，温文尔雅的千金大小姐和泉玲奈（早见沙织 配音），特立独行的孤高展示水无濑小系（内田真礼 配音），这些孩子们集结在一起，为了保护他们挚爱的朋友和家园向怪灵发起了宣战。

What happens when a drunken promise leads to living with a dragon? That’s Miss Kobayashi’s new reality when Tohru appears in her life. With a maid-slash-dragon in her home, she’s experiencing a whole new level of domestic bliss! But the dragons don’t stop there. On a mission to find Tohru appears Kanna, a little dragon with a big attitude. Before she knows it, Kobayashi’s got a house full of dragons—one serving tail and the other serving serious moe! Together, they live side by side with only the occasional disaster…well, maybe. But nothing beats coming home to the warm welcome of a dragon maid!

A strange turn of events leads the Dragon, Tohru, to work as Miss Kobayashi's maid. She occasionally (that's a lie, she often) causes trouble for her beloved Miss Kobayashi while blending into human society and splendidly (that's a lie, only mediocrely) carrying out her maid duties. Her fellow dragons, Kanna, Lucoa, Fafnir, and Elma all find their own places to fit in as well and enjoy interspecies interactions with the humans. Yet while they're all enjoying that laid-back and occasionally turbulent left, the threat of a new Dragon swoops down upon Miss Kobayashi.

在单身的辛苦OL小林身边突然出现的女仆装束的美少女托尔。
长着角和尾巴的她的身姿正是所谓的龙娘。
在醉酒的小林邀请下说要到家里去的托尔，鬼使神差地开始以小林家女仆的身份工作……！？
“女仆”+“龙”=“女仆龙”有着笨手笨脚的可爱之处！
龙娘与人类之间基本上很温暖、偶尔有些黑暗的异种族间交流喜剧！！

This town, is not just a normal town. There's laughter, love and emotional moments. An unpredictable ordinary life presented by the residents! Exciting stuffs come one after another. Welcome to CITY.