The second season of The Twilight Zone aired Fridays at 10:00–10:30 pm on CBS from September 30, 1960 to June 2, 1961. There are 29 episodes.

A man who has a body almost completely covered in tattoos is searching for the woman who cursed him with the "skin illustrations". Each tattoo reveals a bizarre story, which is experienced by staring at the scene depicted. When the illustrated man meets a fellow tramp on the road a strange voyage begins.

David Greene is a New York basketball enthusiast, who wants to coach. He is then offered the coaching job at a small Nevada college. He brings along some players, who are a bit odd but good. Like Swish who unknown to the rest of the team is a girl. Preacher, who's being sought by some nefarious characters. And D.C., who's a fugitive. And along with some of the students at the college, he turns them into a contender. In order to give the tam the respect they deserve and some exposure, Greene schemes to try and get the number 1 team led by Bo Winnegar, to play them.

A wealthy former mental patient goes home to her estate to rest and recuperate. While walking the grounds one day she hears the screams of a woman coming from underneath the ground. Her family, however, refuses to believe her story, and sees the incident as an opportunity to prove the woman's mind has snapped so they can take control of her money.

Christopher Gill is a psychotic killer who uses various disguises to trick and strangle his victims. Moe Brummel is a single and harassed New York City police detective who starts to get phone calls from the strangler and builds a strange alliance as a result. Kate Palmer is a swinging, hip tour guide who witnesses the strangler leaving her dead neighbor's apartment and sets her sights on the detective. Moe's live-in mother wishes her son would be a successful Jewish doctor like his big brother.

A man stumbles out of a car crash with no memory of what transpired. Everyone who he meets suggests that he is a ruthless man with an aggressive temper. Could he be deliberately blocking out memories of his past?

Following World War III, four survivors at an desert military installation attempt to drive across the desolate wasteland of America to Albany, where they hope more survivors are living, using a specially built vehicles to protect themselves against the freakish weather, mutated plant and animal life, and other dangers encountered along the way.

Walter is a successful doctor, and so is his wife Evelyn. Wealthy and good-looking, they should be a happily married couple, but they're not.
Walter is so caught up in his career that he fails to keep up with Evelyn. So when she falls for the charms of Greg, a real estate Romeo, it takes Walter by surprise. Even more so, because he finds out about it from Stephanie, Greg's deserted TV weather girl girlfriend.