Melvin Udall, a cranky, bigoted, obsessive-compulsive writer of romantic fiction, is rude to everyone he meets, including his gay neighbor, Simon. After Simon is brutally attacked and hospitalized, Melvin finds his life turned upside down when he has to look after Simon's dog. In addition, Carol, the only waitress at the local diner who will tolerate him, leaves work to care for her chronically ill son, making it impossible for Melvin to eat breakfast.

A high-strung news producer finds herself in a love triangle between a talented but self-doubting reporter and a charming new anchor, who embodies the growing trivialization of news that she is determined to fight against.

Mexican immigrant and single mother Flor Moreno finds housekeeping work with Deborah and John Clasky, a well-off couple with two children of their own. When Flor admits she can't handle the schedule because of her daughter, Cristina, Deborah decides they should move into the Clasky home. Cultures clash and tensions run high as Flor and the Claskys struggle to share space while raising their children on their own, and very different, terms.

Aurora, a finicky woman, is in search of true love while her daughter faces marital issues. Together, they help each other deal with problems and find reasons to live a joyful life.