Alex Cross, a genius homicide detective/psychologist is trying to clean up the mean streets of Detroit while keeping his family out of the line of fire. As he mulls over accepting a job with the FBI, he is told that a friend has been murdered and he vows to track down the killer. Soon, he and his team are forced to match wits with a psychotic contract killer, who displays a disturbing commitment towards seeing his job through.

After the harrowing death of his partner, forensic psychologist and best-selling author Alex Cross cannot forgive himself and has retreated to the peace of retirement. But when a brilliant criminal kidnaps a senator's young daughter, he is lured back into action as the kidnapper wants to deal with Alex personally. Teamed with Jezzie Flanigan, the Secret Service agent assigned to protect the missing girl, Alex follows a serpentine trail of clues that leads him to a stunning discovery — the kidnapper wants more than just ransom.

Someone is blackmailing the CIA by assassinating foreign journalists and making it look like the agency is responsible. As the world begins to unite against the U.S., the CIA must lure its most brilliant – and rebellious – operative out of retirement, forcing him to confront his checkered past while unraveling an international conspiracy.