Two ex-cons plan to kill the range rider marshal who sent them to prison and, when their plan fails, join forces with their former boss, a crooked saloon owner who has the same idea.

The Stooges run a drug store and are about to have their lease taken away by Amos Flint, the mean old man who owns the place. When Flint kicks his wife out for being too old, the Stooges try to help her by inventing a formula that makes old people young. Their concoction turns the wife into a beautiful young woman, and Flint offers the boys the store for free if they'll transform him as well. They agree, but after he swallows the stuff he turns into an infant, and the boys leave on the run.

The stooges are private detectives looking for a missing millionaire. They wander around the millionaire's spooky mansion confronting various crooks and a dangerous dame. The stooges vanquish the crooks (Shemp uses his "trusty shovel") and find the missing man.

Joe's wife, who thinks he's been carrying on with another woman, moves out.

Shemp has to get married within seven hours in order to inherit $500,000. Now that's incentive! The bumbling threesome set to work right away with hilarious results.