Thankam follows the story of Muthu and Kannan, two gold agents from Thrissur, known as the gold capital of India. As they travel across Kerala and Tamil Nadu, delivering consignments of gold, their lives take a dark turn when a routine trip leads to unexpected complications.

Sachin, a carefree graduate, crosses paths with Reenu, a spirited IT professional, in Hyderabad. As their friendship deepens, unspoken feelings, career ambitions and life choices challenge their bond.

Joji, an engineering dropout and the youngest son of a rich family lives with his aspirations of becoming super wealthy. Driven by greed and blind ambition, he decides to execute his plans following an unexpected event in the family.