Henri “Papillon” Charrière, a safecracker from the Parisian underworld, is wrongfully convicted and sentenced to life imprisonment in the penal colony of French Guiana, where he forges a strong friendship with Louis Dega, a counterfeiter who needs his protection.

When his brother-in-law runs afoul of a drug lord, family man Chris Farraday turns to a skill he abandoned long ago—smuggling—to repay the debt. But the job goes wrong, and Farraday finds himself wanted by cops, crooks and killers alike.