Dr. Génessier is riddled with guilt after an accident that he caused disfigures the face of his daughter, the once beautiful Christiane, who outsiders believe is dead. Dr. Génessier, along with accomplice and laboratory assistant Louise, kidnaps young women and brings them to the Génessier mansion. After rendering his victims unconscious, Dr. Génessier removes their faces and attempts to graft them on to Christiane's.

Set against Paris' oldest bridge, the Pont Neuf, while it was closed for repairs, this film is a love story between two young vagrants: Alex, a would be circus performer addicted to alcohol and sedatives and Michele, a painter driven to a life on the streets because of a failed relationship and an affliction which is slowly turning her blind.