The young and lust filled Blood Sisters find college life the perfect haven for their daily "habit"... Blood. They stalk and seduce their victims by day, then torture and kill them by night. When a chain of strange dissappearances occurs at sexy Tracy's college, fear immediately floods the hallways. Corpses mount at one of the school's sororities. Tracy and her gorgeous roomate, Melissa, join the mysterious sorority hoping to uncover the dark secret. After witnessing brutal slayings, they realize their only salvation lies in the defeat and damnation of the Blood Sisters!

On a hiking trip in the Italian Alps, James discovers an ancient burial cave filled with gladiator artefacts. He becomes possessed by the spirit of Tyranus, a demon gladiator, and goes on a killing spree to revive the true spirit of Demonicus. A professor, Gina, and her students are to be the sacrifices to the demon Tyranus. Can they outwit Demonicus before becoming offerings to the evil god?