The Arizona wilderness, 1880. Gen. Fletcher Blackwell sends a message telling Capt. Walsh, who is escorting a wagon-train through Apache territory, heading for the fort at Furnace Creek, that he should cancel the escort and rush to another town. Apache leader "Little Dog" is leading the attack on the wagon-train and massacring everyone at the poorly manned fort. As a result the treaty is broken with the Indians and the white settlers take over the territory with the help of the cavalry, as the Apaches are wiped out and only "Little Dog" remains at large. Gen. Fletcher Blackwell is court-martial-led for treason.

Gunfighter "Brazos" Kane lays aside his guns "forever" when he is forced to shoot his best friend, and decides to join another friend, Bob Tyrell, as a cowhand on the Inskip ranch. Upon arriving there he finds the bullet-riddled body of his friend. He carries the body to the Banner ranch, the largest in the territory, and is accused by Banner of murdering Tyrell; Banner orders Deputy Sheriff Bill Yount, who is in Banner's pay, to arrest Kane. But Kane has the sympathy of Banner's daughter, Jane, who notifies Inskip of Kane's plight, and Inskip arrives in time to prevent a lynching. Sheriff Kiscade dismisses the murder charge for lack of evidence. Brazos then sets out to find the killer of his friend. Bess Bannister, Jane's sister, is in love with the Banner ranch foreman, Bard Macky, and knowing that Bard killed Tyrell and that Kane will track him down, then hampers Kane's mission somewhat by pretending to be in love with him.

Dinah Sheldon is a student at an exclusive girl's school who starts campaigning for women's rights. Her minister father and her boyfriend Tom Wade do not approve.

A mysterious stranger crosses paths with an outlaw bank robber and a greedy rancher.

A young doctor falls in love with a disturbed young woman and apparently becomes involved in the death of her husband. They head for Mexico trying to outrun the law.