Mean and domineering Jane and the sweet and ditsy Jackie are two radically contrasting sisters who suffer from severe trauma after witnessing the murder/suicide of their parents as well as seeing their other sibling Janice raped and killed by her assailants. The pair are deemed fit to re-enter society and get released from a sanitarium where they have undergone extensive rehabilitation therapy. However, Jane and Jackie prove to be anything but sane and harmless as they embark on a vicious spree in which they torture, murder, and mutilate any man luckless enough to cross their lethal paths.

Frank (Danny Fendley) spent five years in prison for refusing to rat on his boss, Xavier (Joe Estevez). While he was locked up, Xavier inexplicably had Frank's girlfriend killed and took his cash; now that he's out, Frank wants payback. He finds his former employer, but at the same time realizes Xavier's about to do the same thing to another innocent victim. Can Frank exact revenge and save the girl from Xavier's clutches before it's too late?