In 1970s London, Scotland Yard orchestrates the downfall of mob boss Vic Dakin after he crosses the line by blackmailing Members of Parliament.

Jimmy Rabbitte, just a thick-ya out of school, gets a brilliant idea: to put a soul band together in Barrytown, his slum home in north Dublin. First he needs musicians and singers: things slowly start to click when he finds three fine-voiced females virtually in his back yard, a lead singer (Deco) at a wedding, and, responding to his ad, an aging trumpet player, Joey "The Lips" Fagan.

London high-society mouse, Roddy is flushed down the toilet by Sid, a common sewer rat. Hang on for a madcap adventure deep in the sewer bowels of Ratropolis, where Roddy meets the resourceful Rita, the rodent-hating Toad and his faithful thugs, Spike and Whitey.

When young dockworker Jude leaves Liverpool to find his estranged father in the United States, he is swept up by the waves of change that are re-shaping the nation. Jude falls in love with Lucy, who joins the growing anti-war movement. As the body count in Vietnam rises, political tensions at home spiral out of control and the star-crossed lovers find themselves in a psychedelic world gone mad.