After nearly a decade away, Kumail Nanjiani returns to Chicago, where he got his start in standup, in a new special that tackles anxiety, the perils of buying drugs pre-legalization, and most importantly, cat medication.

Pakistan-born comedian Kumail Nanjiani and grad student Emily Gardner fall in love but struggle as their cultures clash. When Emily contracts a mysterious illness, Kumail finds himself forced to face her feisty parents, his family's expectations, and his true feelings.