Space Dandy is a dandy guy, in space! This dreamy adventurer with a to-die-for pompadour travels across the galaxy in search of aliens no one has ever laid eyes on. Each new species he discovers earns him a hefty reward, but this dandy has to be quick on his feet because it's first come, first served! Accompanied by his sidekicks, a rundown robot named QT and Meow the cat-looking space alien, Dandy bravely explores unknown worlds inhabited by a variety of aliens. Join the best dressed alien hunter in all of space and time as he embarks on an adventure that ends at the edge of the universe!

Dandy is a groovy, pompadour-wearing man who explores the stars in search of strange aliens for money, desiring to visit his favorite place: BooBies, the best diner in all the cosmos. Traversing the galaxies in his trusty ship, the Aloha Oe, Dandy is accompanied by his two equally unique friends: QT, the vacuum cleaner robot; and Meow, an alien with a cat-like appearance.

Although exciting, Dandy's job is never simple, and each new day promises a completely different, thrilling adventure. Together, Dandy and his crew get dragged into perilous journeys, misadventures in romance, and out of this world scenarios—all whilst steering clear of the evil scientist, Dr. Gel of the Gogol Empire.