Painter Francisco Goya becomes involved with the Spanish Inquisition after his muse, Inés, is arrested by the church for heresy. Her family turns to him, hoping that his connection with fanatical Inquisitor Lorenzo, whom he is painting, can secure her release.

The story centers on four women and a girl whose lives intertwine with two strangers, one fleeing the other. An injured gunman disrupts their reality, blurring dreams, fears, and desires in a mysterious narrative.

In a fantastical forest we meet some people who have been transported to this place by a magic force. Now their histories cross one another.

At an elder-care facility, a geriatric con artist tries to prevent his new friend with early Alzheimer's symptoms from being transferred to the 'lost causes' floor.

Ramón Sampedro is a ship mechanic and part-time poet left a quadriplegic following a diving accident. Ramón fought for 30 years for the legal right to end his own life. He develops close relationships with his long-term lawyer Julia and his friend Rosa, who tries to convince him that his life is worth living. Despite his situation, Ramón manages to inspire those around him to live life to the fullest.

A woman brings her family back to her childhood home, which used to be an orphanage, intent on reopening it. Before long, her son starts to communicate with a new invisible friend.